HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.
Identifieur interne : 001268 ( Main/Exploration ); précédent : 001267; suivant : 001269HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.
Auteurs : Sebastien Guillaume [France] ; Nader Perroud [Suisse] ; Fabrice Jollant [Canada] ; Isabelle Jaussent [France] ; Emilie Olié [France] ; Alain Malafosse [Suisse] ; Philippe Courtet [France]Source :
- Journal of Psychiatric Research [ 0022-3956 ] ; 2012-11-21.
Descripteurs français
- Wicri :
- topic : Prise de décision.
English descriptors
- mix :
Abstract
Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained alterations in the hypothalamic-pituitary-adrenal axis (HPA axis). Here, we aimed to investigate the effect of childhood trauma and its interaction with HPA-axis related genes on decision-making abilities in adulthood among a sample of suicide attempters. The Iowa Gambling Task (IGT) was used to assess decision-making in 218 patients with a history of suicide attempt. Participant fulfilled the Childhood Trauma Questionnaire to report traumatic childhood experiences. Patients were genotyped for single-nucleotide polymorphisms within CRHR1 and CRHR2 genes. Patients with a history of sexual abuse had significantly lower IGT scores than non-sexually abused individuals. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence IGT performance. In conclusion, childhood sexual abuse and emotional neglect may have long-term effects on decision-making through an interaction with key HPA axis genes. Even if these results need to be replicated in other sample, impaired decision-making may thus be the dimension through which child maltreatment, in interaction with HPA axis related genes, may have a sustained negative impact on adult mental health.
Url:
DOI: 10.1016/j.jpsychires.2012.10.014
Affiliations:
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Montréal (Québec) Canada H3A 0G4</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.mcgill.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-350985" type="direct"><org type="institution" xml:id="struct-350985" status="INCOMING"> <orgName>Douglas Mental Health University Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Jaussent, Isabelle" sort="Jaussent, Isabelle" uniqKey="Jaussent I" first="Isabelle" last="Jaussent">Isabelle Jaussent</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-74735" status="INCOMING"> <orgName>Urgence et post-urgence psychiatrique</orgName> <desc> <address> <addrLine>371, avenue du Doyen 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</org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Olie, Emilie" sort="Olie, Emilie" uniqKey="Olie E" first="Emilie" last="Olié">Emilie Olié</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-74735" status="INCOMING"> <orgName>Urgence et post-urgence psychiatrique</orgName> <desc> <address> <addrLine>371, avenue du Doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-258773" type="direct"></relation> <relation active="#struct-300154" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-258773" type="direct"><org type="institution" xml:id="struct-258773" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName> <orgName type="acronym">CHRU Montpellier</orgName> <desc> <address> <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-montpellier.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300154" type="direct"><org type="institution" xml:id="struct-300154" status="INCOMING"> <orgName>Hôpital Lapeyronie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-208421" status="INCOMING"> <orgName>Department of Medical Genetics and Laboratory</orgName> <desc> <address> <addrLine>2 ch Petit Bel-Air, CH-1225 Chêne-Bourg</addrLine> <country key="CH"></country> </address> </desc> <listRelation> <relation active="#struct-300992" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300992" type="direct"><org type="institution" xml:id="struct-300992" status="VALID"> <orgName>Geneva University Hospital</orgName> <orgName type="acronym">HUG</orgName> <desc> <address> <country key="CH"></country> </address> <ref type="url">https://www.hug-ge.ch/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Suisse</country></affiliation></author><author><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-74735" status="INCOMING"> <orgName>Urgence et post-urgence psychiatrique</orgName> <desc> <address> <addrLine>371, avenue du Doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-258773" type="direct"></relation> <relation active="#struct-300154" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-258773" type="direct"><org type="institution" xml:id="struct-258773" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName> <orgName type="acronym">CHRU Montpellier</orgName> <desc> <address> <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-montpellier.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300154" type="direct"><org type="institution" xml:id="struct-300154" status="INCOMING"> <orgName>Hôpital Lapeyronie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.jpsychires.2012.10.014</idno><series><title level="j">Journal of Psychiatric Research</title><idno type="ISSN">0022-3956</idno><imprint><date type="datePub">2012-11-21</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Attempted suicide</term><term>Attempted suicide.</term><term>Child abuse</term><term>Decision-making</term><term>Gene Environment Interaction</term><term>Stress</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prise de décision</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained alterations in the hypothalamic-pituitary-adrenal axis (HPA axis). Here, we aimed to investigate the effect of childhood trauma and its interaction with HPA-axis related genes on decision-making abilities in adulthood among a sample of suicide attempters. The Iowa Gambling Task (IGT) was used to assess decision-making in 218 patients with a history of suicide attempt. Participant fulfilled the Childhood Trauma Questionnaire to report traumatic childhood experiences. Patients were genotyped for single-nucleotide polymorphisms within CRHR1 and CRHR2 genes. Patients with a history of sexual abuse had significantly lower IGT scores than non-sexually abused individuals. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence IGT performance. In conclusion, childhood sexual abuse and emotional neglect may have long-term effects on decision-making through an interaction with key HPA axis genes. Even if these results need to be replicated in other sample, impaired decision-making may thus be the dimension through which child maltreatment, in interaction with HPA axis related genes, may have a sustained negative impact on adult mental health.</p> </div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li><li>Suisse</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Guillaume, Sebastien" sort="Guillaume, Sebastien" uniqKey="Guillaume S" first="Sebastien" last="Guillaume">Sebastien Guillaume</name></noRegion><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name><name sortKey="Jaussent, Isabelle" sort="Jaussent, Isabelle" uniqKey="Jaussent I" first="Isabelle" last="Jaussent">Isabelle Jaussent</name><name sortKey="Olie, Emilie" sort="Olie, Emilie" uniqKey="Olie E" first="Emilie" last="Olié">Emilie Olié</name></country><country name="Suisse"><noRegion><name sortKey="Perroud, Nader" sort="Perroud, Nader" uniqKey="Perroud N" first="Nader" last="Perroud">Nader Perroud</name></noRegion><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name></country><country name="Canada"><region name="Québec"><name sortKey="Jollant, Fabrice" sort="Jollant, Fabrice" uniqKey="Jollant F" first="Fabrice" last="Jollant">Fabrice Jollant</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Hal:inserm-00759957
|texte= HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.
}}
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